Toxic dermatitis induced by 10-ethyl-10-deazaaminopterin (10-EdAM), a novel antifolate
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چکیده
منابع مشابه
Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate.
The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than methotrexate in murine tumor models and human tumor xenografts. Their design was aimed at improving membrane transport and polyglutamylation in tumor cells, resulting in increased intracellular accumulation and enhanced cytotoxicity. Compared with other 4-aminofolate analogue...
متن کاملPhase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer.
10-Ethyl-10-deazaaminopterin (10-EDAM) is an analogue of methotrexate with improved preclinical anticancer activity, more selective entry, and greater conversion to polyglutamate forms in neoplastic cells. In this Phase I trial, we have treated 62 adults with advanced solid tumors, giving 10-EDAM i.v. on either a weekly x 3 schedule (35 patients) or a weekly schedule (27 patients). The dosage l...
متن کاملIntracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.
Administration i.p. of 10-ethyl-10-deazaaminopterin (10EDAM) with cis-diamminedichloroplatinum(II) (cis-Pt) had significant antitumor activity against the murine ovarian tumor. This tumor is a teratoma originating in the ovary with pathogenesis and metastatic properties similar to those of human ovarian cancer. Drug was given on a schedule of once every 3 days for 3 doses 1 or 2 days after i.p....
متن کاملTox¡city, Elimination, and Metabolism of 10-Ethyl-lO-deazaaminopterin in Rats and Dogs1
10-Ethyl-lO-deazaaminopterin (10-EdAM) is an antifolate compound with greater therapeutic activity than methotrexate against transplanted tumors in mice. When given weekly for 3 weeks, the 10% lethal dose in rats was 125 mg/kg (i.p.) and in dogs it was 2.5 mg/kg (i.v.). The major histopathological findings in intoxicated animals were damage to the mucosa of the gastrointestinal tract in rats an...
متن کامل9-Ethyl-10-methylacridinium trifluoromethanesulfonate
In the mol-ecule of the title compound, C(16)H(16)N(+)·CF(3)SO(3) (-), the central ring adopts a flattened-boat conformation, and the two aromatic rings are oriented at a dihedral angle of 3.94 (2)°. In the crystal structure, weak inter-molecular hydrogen bonds link the mol-ecules. There are π-π contacts between the aromatic rings and the central ring and one of the aromatic rings [centroid-cen...
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ژورنال
عنوان ژورنال: Cancer
سال: 1990
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19901101)66:9<1910::aid-cncr2820660909>3.0.co;2-2